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IEEE Open J Eng Med Biol ; 2: 111-117, 2021.
Article in English | MEDLINE | ID: covidwho-1242135

ABSTRACT

Goal: The COVID-19 pandemic has emerged as the most severe public health crisis in over a century. As of January 2021, there are more than 100 million cases and 2.1 million deaths. For informed decision making, reliable statistical data and capable simulation tools are needed. Our goal is to develop an epidemic simulator that can model the effects of random population testing and contact tracing. Methods: Our simulator models individuals as particles with the position, velocity, and epidemic status states on a 2D map and runs an SEIR epidemic model with contact tracing and testing modules. The simulator is available on GitHub under the MIT license. Results: The results show that the synergistic use of contact tracing and massive testing is effective in suppressing the epidemic (the number of deaths was reduced by 72%). Conclusions: The Particle-based COVID-19 simulator enables the modeling of intervention measures, random testing, and contact tracing, for epidemic mitigation and suppression.

2.
IEEE J Biomed Health Inform ; 24(10): 2743-2754, 2020 10.
Article in English | MEDLINE | ID: covidwho-694260

ABSTRACT

In this work, we present an open-source stochastic epidemic simulator calibrated with extant epidemic experience of COVID-19. The simulator models a country as a network representing each node as an administrative region. The transportation connections between the nodes are modeled as the edges of this network. Each node runs a Susceptible-Exposed-Infected-Recovered (SEIR) model and population transfer between the nodes is considered using the transportation networks which allows modeling of the geographic spread of the disease. The simulator incorporates information ranging from population demographics and mobility data to health care resource capacity, by region, with interactive controls of system variables to allow dynamic and interactive modeling of events. The single-node simulator was validated using the thoroughly reported data from Lombardy, Italy. Then, the epidemic situation in Kazakhstan as of 31 May 2020 was accurately recreated. Afterward, we simulated a number of scenarios for Kazakhstan with different sets of policies. We also demonstrate the effects of region-based policies such as transportation limitations between administrative units and the application of different policies for different regions based on the epidemic intensity and geographic location. The results show that the simulator can be used to estimate outcomes of policy options to inform deliberations on governmental interdiction policies.


Subject(s)
Coronavirus Infections/epidemiology , Coronavirus Infections/prevention & control , Epidemics/statistics & numerical data , Models, Biological , Pandemics/prevention & control , Pneumonia, Viral/epidemiology , Pneumonia, Viral/prevention & control , Betacoronavirus , COVID-19 , Computational Biology , Computer Simulation , Coronavirus Infections/transmission , Epidemics/prevention & control , Health Policy , Humans , Italy/epidemiology , Kazakhstan/epidemiology , Models, Statistical , Pandemics/statistics & numerical data , Pneumonia, Viral/transmission , SARS-CoV-2 , Stochastic Processes , Transportation
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